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[null,"Fields in light blue are required."]
[]
[null,"Customer Information:"]
[null,"Service Requestor's Information"]
[null,"Date of Request"]
[]
[null,"Customer Company/Institute Name:"]
[null,"Primary Customer Contact Name:"]
[null,"Customer Department:"]
[null,"Customer Title:"]
[null,"Customer Email:"]
[null,"Customer Phone:"]
[]
[null,"Requestor's Purchasing Contact Information"]
[null,"Purchasing Contact Name:"]
[null,"Purchasing Contact Title:"]
[null,"Purchasing Contact Email:"]
[null,"Purchasing Contact Phone:"]
[]
[null,"Requestor's Bionano Business/Sales Person Contact Information"]
[null,"Bionano Contact Name: "]
[]
[null,"Project Plans and Goals "]
[null,"What is the objective/pathology or application for your project?"]
[null,"(Provide a written description of the project and the desired analyses required for your samples):"]
[]
[]
[null,"Would you be interested in adopting Bionano's technology if this project is able to help answer your stated objectives/hypotheses?"]
[]
[null,"References:"]
[]
[]
[null,"Data Review:"]
[null,"Would you like the option to bulk download your data via a AWS S3 bucket?"]
[null,"(Please note that standard data delivery includes the option to download data from us.bionanoaccess.com.  Access to the S3 bucket will be given for only 1 week.)"]
[null,"Note: All data will be removed after 6 and before 12 months of storage unless otherwise specified."]
[null,"Note: Bionano Access software demos and data review presentations can be expected to take place ~2 weeks after date of data delivery to customer."]
[]
[null,"Publication Information"]
[null,"Would you be interested in presenting this work at a conference? "]
[null,"Do you have plans to publish this work? If so, in which journal(s)?"]
[]
[null,"Development and Database Contribution"]
[null,"Bionano is building databases of structural variation data to help interpret variants by providing allele frequency in a population or information about a variant’s previous detection in a clinical case. We are looking for customers willing to allow Bionano to use your data in this way or for other research and development activities. All data will be anonymized, and no protected health information will be used or stored. "]
[null,"Please sign if you are willing to share your data for Bionano’s control structural variant database and internal development:"]
[null,"I, Click or tap here to enter text,",null," to share data with Bionano Genomics for use in an anonymized database and/or technology development purposes. "]
[]
[]
[null,"Note: Services through the Bionano Data Services Laboratory are designed for proof of concept studies and we are not in the capacity to offer long-term CRO services."]

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[]
[null,"Sample Information:"]
[null,"Sample Storage Conditions"]
[null,"What temperature were samples kept at before freezing?"]
[null,"How long were your samples kept at this temperature (prior to freezing)?"]
[null,"At what temperature were the frozen samples stored (-20/-80C)?"]
[null,"How long have the samples been kept frozen?"]
[null,"Have the samples ever been thawed and refrozen?"]
[null,"Did you count or weigh the samples before freezing?"]
[null,"      If so, what system did you use for counting cells?"]
[null,"Did you account for cell viability before freezing?"]
[null,"If so, what is the range of cell viability for all samples?"]
[null,"Have any other assays or QCs been done on the sample (e.g. Bionanalyzer)?"]
[]
[null,"Sample Safety/Biohazard"]
[null,"What is the biosafety level of your samples?  "]
[null,"Please describe any specific hazards:"]
[null,"Note: Only biosafety levels 1 and 2 are accepted."]
[]
[null,"Privacy"]
[null,"Have your samples been de-identified?"," "]
[null,"Note: No protected health information (PHI) should be included with your sample. If samples are received with PHI, they will be returned."]
[]
[null,"Sample Return"]
[null,"If remnant is available, would you like your sample and/or extracted DNA returned?"]
[null,"Do you have any specific requests for the remnant sample and DNA?"]
[null,"Note: Returning sample will incur a shipping cost. All samples and related material will be destroyed after 6 and before 12 months of storage unless otherwise specified."]
[]
[null,"Analysis Information:"]
[null,"Background"]
[null,"What is the expected level of heterogeneity?"]
[null,"What percentage allele fraction sensitivity is expected/required for relevant variants?"]
[null,"Please describe any additional filtering you would like us to apply to the SV call sets:"]
[null,"(e.g. a BED file of known regions of interest. Samples are annotated against the Bionano control sample SV database by default)."]
[null,"Please describe any custom data analysis or applications of OGM technology which are not covered in our standard offering (custom work may incur additional cost):"]
[null,"Note: All data will be removed after 6 and before 12 months of storage unless otherwise specified."]

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[]
[null," Ship From:",null,"Sample Sheet",null,null," Ship To:",null,"Bionano - San Diego",null,null,null,"Important Note"]
[null,null,null,null,null,null,{"$f":"IF($I$2=\"Bionano - San Diego\", \"Attn: Data Services Lab\", IF($I$2=\"Bionano - Clermont-Ferrand\", \"Attn: Michaela West\", \"\"))","v":"Attn: Data Services Lab"}]
[null,null,null,null,null,null,{"$f":"IF($I$2=\"Bionano - San Diego\", \"Bionano\", IF($I$2=\"Bionano - Clermont-Ferrand\", \"Site INRAE de Crouël\", \"\"))","v":"Bionano"},null,null,null,null,null,"Instructions\nPlease return this entire form to your Bionano Business/Sales Person for approval — you must receive approval before shipping your samples. \nInclude an additonal paper copy of the Sample Sheet with your shipped samples."]
[null,null,null,null,null,null,{"$f":"IF($I$2=\"Bionano - San Diego\", \"6777 Nancy Ridge Dr\", IF($I$2=\"Bionano - Clermont-Ferrand\", \"5 Chemin de Beaulieu\", \"\"))","v":"6777 Nancy Ridge Dr"}]
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[null,null,null,null,null,null,{"$f":"IF($I$2=\"Bionano - San Diego\", \"Tel:  +1 (858) 888-7600\", IF($I$2=\"Bionano - Clermont-Ferrand\", \"+33 (0)6 73 20 67 66\", \"\"))","v":"Tel:  +1 (858) 888-7600"}]
[null,null,null,null,null,null,"dataservices@bionano.com"]
[]
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[]
[null,"Customer Institution",{"$f":"'Project Overview and Goals'!C7&\"\"","v":""},null,null,null,"Date Shipped:",null,null,null,null,null,"Date Received:",null,"Bionano use only"]
[]
[null,"Total Samples",{"$f":"IF(COUNTA(B21:B116)>0,COUNTA(B21:B116),\"\")","v":""},null,null,null,"Sample/DNA Return",null,{"$f":"'Sample and Analysis Details'!C25&\"\"","v":""},null,null,null,"Bionano Quote No.",null,"Bionano use only"]
[]
[null,"Biohazard Level",{"$f":"'Sample and Analysis Details'!C16&\"\"","v":""},null,null,null,"Data Use Consent",null,{"$f":"'Project Overview and Goals'!C46&\"\"","v":""},null,null,null,"Salesforce Opportunity URL",null,"Bionano use only"]
[]
[null,"Sample Name","Sample Type","Quantity\n","Number of Aliquots","Organism","Reference Genome","Coverage Target","Application Desired","Sex","Variant Annotation","Sample Relationship","Dual Analysis","Trio Analysis",null,"Objective or Pathology","Region of Interest","Additional Details","Analysis Comments"]
[null,"(de-identified)","(please specify cell or tissue types in \"additional details\")","(#cells, volume blood or BMA, mass tissue)",null,"(please use binomial name, e.g. Genus species)","(multiselect if necessary)",null,"(multiselect if necessary)",null,"(multiselect if necessary)","(multiselect if necessary)","Dual Control \n(Sample ID or N/A)","Father/Sample 2 (Sample ID or N/A)","Mother/Sample 3 (Sample ID or N/A)","(e.g. ALL, AML, FSHD, edited genome QC, etc…multiselect if necessary)","(e.g. genomic coordinates, genes of interest, size and type of SV expected)","(please indicate cell or tissue type, polyploidy, custom analysis requests, etc.)","(Bionano use only)"]
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[]
[null,"Sample Information"]
[null,"Two or more aliquots per sample must be submitted so one can be used as a backup. Each aliquot should be prepared from a fresh sample with no prior freeze/thaw cycles. All frozen samples should be frozen as soon as possible, never thawed and shipped on dry ice. "]
[null,"Routine sample types will have a faster turnaround time. Expected turnaround times are based on batch sizes of 12 or fewer. Larger projects will have a rolling delivery, with the first batch of 12 samples completed within the time frame below. More details about sample types in appendix."]
[]
[null,"Sample Type††","Recommended Quantity Per Aliquot","Expected turnaround time"]
[null,"Frozen blood (EDTA)","650 uL","6 weeks"]
[null,"Frozen blood (Heparin)","† 650 uL (with Bionano DNA stabilizer added)","6 weeks"]
[null,"Live LCL culture","Healthy cells in T25 flask (1.5 million cells)","8-10 weeks"]
[null,"Frozen cells (cryopreserved)",">1,500,000 live cells/mL (in cryopreservative) ","8-10 weeks"]
[null,"Frozen cells (dry) pellet","‡ 1.5 million cells (washed in Bionano DNA stabilizing buffer)","8-10 weeks"]
[null,"Frozen bone marrow aspirate (EDTA)","1 mL","6 weeks"]
[null,"Frozen bone marrow aspirate (Heparin)","† 1 mL (with Bionano DNA stabilizer added)","6 weeks"]
[null,"Cryopreserved amniocyte/CVS culture",">1,500,000 live cells (in cryopreservative)","6 weeks"]
[null,"Frozen pellet from amniocyte/CVSculture","1.5 million cells (washed in Bionano DNA stabilizing buffer)","6 weeks"]
[null,"Frozen tissue, high nuclei content","≥ 10 mg, 30 preferred*","8-10 weeks"]
[null,"Frozen tissue, low nuclei content","≥ 60+ mg**","8-10 weeks"]
[null,"†   heparin blood and heparin bone marrow aspirates require the addition of Bionano DNA Stabilizer prior to freezing (PN 20398)."]
[null,"‡   It is recommended to prepare frozen cells using cryopreservation medium. If this is not possible, then DNA Stabilizing Buffer (PN 20394 and 20397) should be used to remove residual growth medium before freezing. Consult with a Bionano associate for more details."]
[null,"††  see details in shipping guidelines documents"]
[null,"*  tissue with high nuclei content relative to the tissue mass: Liver, thyroid, bladder, brain, spleen, lung, kidney, ovary, spleen."]
[null,"** tissue with low nuclei content relative to the tissue mass: Breast and some fatty tissues as well as most muscle tissue."]
[]
[null,"Important Notes:"]
[null,"Please note some important limitations to analysis with Saphyr: "]
[null,"· Germ line analysis (100x coverage) – Utilize the Bionano Solve De Novo Pipeline to detect diploid or genetic disease samples which may have insertions and deletions at larger than 500 bp or balanced and unbalanced translocations larger than 50 kbp; and inversions and duplications larger than 30 kbp"]
[null,"· Cancer or heterogeneous samples (400x) - Utilize the Bionano Rare Variant Analysis (RVA) pipeline to detect SVs at 5 kbp for insertions and deletions at 5% variant allele fraction.  Refer to the Document Structural Variant Calling - 30110 -Theory of Operations for more information on detectable size of other SVs and LOD."]
[null,"· Dual or Trio analyses - Setup tumor-normal comparisons to identify tumor-specific somatic variants or trio analysis in constitutional samples to identify inherited or de novo variants."]
[null,"· Cell line or Other Mosaic Samples (1600x) -  For projects requiring up to 1% allele fraction for SVs (10% allele fraction for CNVs), please consult with the data services technical team. May require 10+ weeks TAT."]
[]
[null,"· The CNV algorithm detects CNVs >=500 kbp. Output as part of both the De novo Assembly and rare variant pipeline."]
[null,"· Absence of heterozygosity (AOH) can now be detected in germ line DNA (not mosaic/somatic) for regions larger than 25-40 Mbp. Not compatible with the rare variant pipeline."]
[null,"· Heterochromatic regions of the genome are often not assembled in the human reference and Bionano may not have enough information to analyze these regions (this includes Robertsonian translocations and balanced translocations with centromeric breakpoints). "]
[]
[null,"Technical Assistance"]
[null,"For technical assistance, contact Bionano Genomics Technical Support."]
[null,"You can retrieve documentation on Bionano products, SDS's, certificates of analysis, frequently asked questions, and other related documents from the Support website or by request through e-mail and telephone."]
[null,"Type","Contact"]
[null,"Email","support@bionano.com"]
[null,"Phone","Hours of Operation: "]
[null,null,"Monday through Friday, 9:00 a.m. to 5:00 p.m., PST "]
[null,null,"US: +1 (858) 888-7663"]
[null,"Website","www.bionano.com/support"]
[]
[null,"Appendix"]
[null,"Please see https://bionano.com/products/bionano-data-services/ for more details"]

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{"sheet":"Data Validation","index":5,"n_rows":47,"n_cols":14,"rows_kept":47,"cut":false,"hidden":true,"merged":[]}
["sample type","Organism","Reference Genome","Coverage Target","Application Desired","Variant Annotation","Sample Relationship","Sex","Sample/DNA Return","Data Use Consent","Biohazard Level",null,"Objective or Pathology","Major Application"]
["Frozen cells (cryopreserved)","Homo sapiens","hg19/grch37 (human)","100X (400 Gbp)","De novo Assembly","Single","Control","Male","Yes - DNA","Consent","Non-biohazardous",null,"ALL","Reproductive Disorders and Prenatal-constitutional"]
["Frozen cells (dry pellet)","Mus musculus","hg38/grch38 (human)","200X (800 Gbp)","Rare Variant Analysis","Dual","Case","Female","Yes - Sample","Do not consent","Biosafety level 1",null,"AML","Postnatal-constitutional"]
["Frozen blood (EDTA)","Saccharomyces cerevisiae","GRCm38/mm10 (mouse)","400X (1.5 Tbp)","FSHD","Trio","Edited","N/A","Yes - DNA and Sample","Yes","Biosafety level 2",null,"Animal","Heme"]
["Frozen blood (Heparin) with DNA stabilizer","Danio rario","No reference","Up to 1600X (5 Tbp)","Fragile X",null,"Unedited",null,"No","No",null,null,"ATRT","Solid Tumor"]
["Frozen blood (Heparin) without DNA stabilizer","Drosophila melanogaster","Other","Other","Hybrid Scaffolding",null,"Tumor",null,"Unknown",null,null,null,"Brain","Human Research"]
["Frozen bone marrow (EDTA)","Caenorhabditis elegans",null,null,"Other",null,"WT",null,null,null,null,null,"Breast","Cell QC/Manufacturing"]
["Frozen bone marrow (Heparin) with DNA stabilizer","Xenopus tropicalis",null,null,null,null,"Proband",null,null,null,null,null,"Cancer","Non-Human"]
["Frozen bone marrow (Heparin) without DNA stabilizer","Other",null,null,null,null,"Father",null,null,null,null,null,"Cell QC/Manufacturing","Technology Development"]
["Frozen soft tissue",null,null,null,null,null,"Mother",null,null,null,null,null,"CLL","Other"]
["Frozen fatty or fibrous tissue",null,null,null,null,null,"Sibling",null,null,null,null,null,"CML"]
["Dataset only",null,null,null,null,null,"Other",null,null,null,null,null,"Colon and rectum"]
["Other",null,null,null,null,null,null,null,null,null,null,null,"Constitutional"]
[null,null,null,null,null,null,null,null,null,null,null,null,"COVID-19"]
[null,null,null,null,null,null,null,null,null,null,null,null,"DMD"]
[null,null,null,null,null,null,null,null,null,null,null,null,"FSHD"]
[null,null,null,null,null,null,null,null,null,null,null,null,"FXS"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Heme"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Hepatocellular Carcinoma"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Genome Assembly"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Human Research"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Leukemia"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Lung and bronchus"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Lymphoma"]
[null,null,null,null,null,null,null,null,null,null,null,null,"MDS"]
[null,null,null,null,null,null,null,null,null,null,null,null,"MDS/MPN"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Melanoma"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Microdel/microdup"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Multiple Myeloma"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Musculoskeletal"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Neurodevelopmental Disorder (NDD)"]
[null,null,null,null,null,null,null,null,null,null,null,null,"None"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Non-Human"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Other"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Plant"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Postnatal Constitutional"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Preimplantation Genetic Testing (PGT)"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Prenatal"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Prostate"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Repeat Expansions/Contractions"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Reproductive Disorder"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Schizophrenia"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Solid Tumor"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Stem Cell"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Syndromic (Downs/microdel/dup)"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Technology Development"]
[null,null,null,null,null,null,null,null,null,null,null,null,"Thyroid"]